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Nutritional Supplements
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Don’t Take That Drug Without the Right Supplement
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In my early days as a cardiologist, I treated a woman named Charlotte for high blood pressure. As was (and still is) the medical standard, I prescribed a diuretic. Three days later and in a panic, she called the office because she was feeling muscle pain, weakness, and terrible fatigue, and she was having extreme difficulty walking and performing her daily routines.
I dispatched a technician to her house to draw blood for an electrolyte count, which showed that her body had been depleted of potassium. I told her to start eating bananas and oranges—both are good food sources of potassium—and I sent her a potassium supplement. Just a day later, she was much better.
Charlotte’s predicament shocked me. It was my first encounter with a major pharmaceutical side effect, and it was a wake-up call about the negative effects that prescription drugs can have on a patient’s nutritional status.
For most doctors, this issue doesn’t even appear on their radar screens. And, of course, pharmaceutical companies aren’t particularly interested in publicizing how their products can sap you of the basic nutrients you need to remain healthy. But I’m here to tell you that not only do all drugs have side effects, those side effects are often the result of interference with nutrient-specific enzymatic reactions— and they can have serious and sometimes deadly consequences. Here’s what I mean.
Drugs Rob You of Nutrients
Your body breaks food into nutrients through the process of digestion. The nutrients then pass into the bloodstream and are transported to cells throughout the body—a process referred to as absorption. Finally, the cells put the nutrients to work in various biochemical processes, which is called synthesis. Collectively, these processes of digestion, absorption, and synthesis are how your body is nourished.
Pharmaceuticals almost universally disrupt this “nutritional sequence.” The point at which the disruption occurs is usually described as a drug’s biochemical pathway, or its mechanism of action. You can also think of this as the point at which the drug causes the body to do something it wouldn’t naturally do. In Charlotte’s case, the diuretic increased her urine production (read more about diuretics in the above sidebar box). The drug worked like a charm. But what I hadn’t thought about were the minerals often passed in urine: potassium and sodium. The more often Charlotte went to the bathroom, the more potassium she lost. Eventually, the effects of this depletion became overwhelming.
Whenever you tamper with biochemical pathways on a regular basis, as is true of people who take a daily medication, you make the body vulnerable to nutrient deficiencies. That’s why, when drugs are used on a regular basis, the risk-to-benefit ratio must always be calculated, and one of the risks that must be considered is the drug’s impact on nutrition— especially in elderly patients who take multiple medications.
Sickness and death from pharmaceutical prescriptions have reached epidemic proportions, and I believe this is one of the reasons why. Much more focus, research, and alertness is needed. Whenever I prescribe drugs I also prescribe supplements to offset the negative effects of a medication. Moreover, the additional nutritional support helps medications work more effectively (and often at lower doses) because it strengthens the body.
Top Three Medications by Sales in the US
Take These With Your Prescriptions
I could easily fill this entire newsletter outlining which nutrients are depleted by which drugs. So, for brevity, I’ve listed some of the most commonly prescribed medications (and a few over-the-counter ones, too) and how they affect the body. If you’re taking any of them, be sure that you’re also supplementing with the appropriate nutrients. The amount of a supplement you’ll need will depend on your overall health and your medication dosage, but, in many cases, you’ll be off to a good start if you’re taking a high-quality daily multinutrient.
My advice to you is to make sure you truly need any medication you take and fully understand how the drug works and what nutrients it may be affecting. Then supplement appropriately to protect your health.
This article originally appeared in the March 2008 issue of Dr. Sinatra’s monthly written newsletter, Heart, Health & Nutrition. HMDI has reprinted this article with permission from Healthy Directions, LLC ((© 2008 Healthy Directions, LLC).
References
Rietzschel E, et al. Anticonceptive drug use and increased carotid and femoral plaque prevalence. American Heart Association conference 2007; Abstract 3614.
Schurgers LJ, et al. Post-translational modifications regulate matrix Gla protein function: Importance for inhibition of vascular smooth muscle cell calcification. J Thromb Haemost. 2007;5(12):2503–2511.
Whittaker P, Donovan JL, Przyklenk K. Long-term warfarin therapy is associated with tissue calcification. J Thromb Thrombolysis. 2008;25(1):125.
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Dangers of Diuretics
Some 25 to 40 percent of adults age 65 and older use diuretics. Diuretics increase urine production, which promotes excretion of more than the normal amount of sodium, potassium, and water. The result is less fluid flowing through the blood vessels, which reduces pressure on arterial walls. While this may be good for your blood pressure, it’s not so good for your body chemistry. All of the enzymatic processes that require sodium and potassium have less of those minerals available to them.
Thiazides, a specific class of diuretics, remain a first choice for treating high blood pressure and hypertension-related heart problems. Other types of diuretics can be prescribed to prevent, treat, or improve symptoms in a variety of conditions, such as congestive heart failure and edema. But they all work the same way—and other classes of diuretics have been documented to deplete calcium, B-complex vitamins, and vitamin C
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For more information, check out "The Power of Ginger" at http://blog.drsinatra.com/blog/heart-health-nutrition/the-power-of-ginger
and "Does Aspirin Therapy Really Work?" at http://blog.drsinatra.com/blog/heart-health-nutrition/does-aspirin-therapy-really-work
Best of health and happiness!