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Nutritional Supplements
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D-Ribose
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D-ribose is a simple sugar found in every cell of your body. Not only is it a structural component of the ATP molecule, D-ribose also helps comprise genetic materials, deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). While coenzyme Q10 (CoQ10) and L-carnitine both directly support ATP recycling, the most efficient means of cardiac energy metabolism, D-ribose helps ensure there’s enough original ATP synthesized for your mitochondria to recycle.
Unlike other sugars, D-ribose is not normally used by your body for fuel. Instead, so that it can make ATP and genetic material, your body saves some of the glucose it would use for glycolysis, or fuel production, to produce D-ribose. As you synthesize D-ribose in response to specific metabolic demands, and don’t store this sugar in its free form in your body, there is no “normal” level to measure deficiency against.
Whether one needs to supplement with D-ribose depends on one's lifestyle and state of health. Generally, the body makes enough D-ribose in tissues like the heart, skeletal muscle, nerve tissue, and the brain to meet its daily metabolic needs. However, people whose cells and tissues are oxygen depleted, or because of illness are otherwise metabolically challenged, may be deficient in D-ribose. Because their energy demands exceed what their bodies are able to produce, people with ischemic heart disease, congestive heart failure (CHF), hypertension, fibromyalgia, and chronic fatigue syndrome, in addition to serious athletes, need to supplement with D-ribose.
Oxygen deprivation, which characterizes ischemic heart disease, forces the body make energy through a means other than oxidative phosphorylation. To survive, the body will switch to glycolysis, or glucose metabolism, a much less metabolically efficient, albeit very important, process which provides the body large amounts of energy in short bursts. The problem with glycolysis replacing oxidative phosphorylation as the primary means of energy production is that it will cause exhaustion over time. The body, no longer able to recycle ATP, will also become unable to synthesize it de novo, as the glucose it would have reserved for D-ribose synthesis is eventually used for fuel.
Remember in energy utilization, the body breaks ATP down into ADP, which it recycles into ATP again. Under disease conditions of greater energy need, the body will start breaking down ADP for energy rather than recycle it back into ATP. The resulting AMP molecules, incompatible with sustained cellular function, are quickly broken apart. The byproducts of AMP molecules, D-ribose and adenine, get washed out of cells, which deprives the body of an energy substrate supply with which to synthesize ATP de novo.
People with ischemia, diastolic dysfunction, or other compromising conditions need to supplement with D-ribose to replenish their energy pool and normalize cardiac function. For healthier individuals, D-ribose supplementation can alleviate symptoms of discomfort following exercise. Athletes can attenuate shaky weak limbs and fatigue following strenuous exercise and non-athletic people can avoid delayed onset muscle soreness. Supplementation with D-ribose serves as a rate-limiting step: it surpasses the need for D-ribose synthesis, a slow process which must be accomplished before ATP synthesis can begin. In other words, supplementing with D-ribose helps one faster generate energy.
D-ribose is quickly and easily absorbed through your gut into the blood. The amount of supplemental D-ribose you need generally depends on whether you have been subject to chronic oxygen depletion or have circulatory problems. Circulation is the most important consideration, as ischemic blood flow can result in delayed D-ribose delivery. Since D-ribose only stays in your blood for 30 minutes, higher doses taken daily are recommended if you suffer from an ischemic condition.
Dr. Sinatra recommends:
© 2010 Heart MD Institute, PA
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Comments
As for the emails you're receiving, HMDI only sends them out periodically (currently @ 3-5 a year). There should be a link in that email through which you may "unsubscribe." Perhaps you are receiving free e-letters from Drsinatra.com instead? You should also be able to unsubscribe to the list via a link embedded in the email. Best of health and happiness!
As for informational resources, we have an article that may be helpful to you at http://www.heartmdinstitute.com/health-concerns/cardiovascular-system/cholesterol/lets-clear-up-cholesterol-confusion-once-for-all-
Drsinatra.com also offers some online info about cholesterol... you can visit the Health Center at http://resources.drsinatra.com/cholesterol to access several articles about cholesterol. You may also want to visit http://blog.drsinatra.com/ and search for cholesterol-related blogs, especially those about niacin, as it helps small particle LDL to be more fluffy and less toxic.
We also suggest reading Reverse Heart Disease Now, which addresses small particle LDL and arterial inflammation, as well as The Biology of Belief by Dr. Bruce Lipton, a revolutionary book exploring the power we have to shape our health, and that genetic determinism is not absolute.
Best of health and happiness to you!
On Amioderone, Xarelto, Lisinopril and Carvedilol
7 days after discharge went into A-flutter... about 8 days later converted back on its own.
I'm now on track to have cryo-ablation next Friday.
What are your thoughts on having this done? Seems to me I have to since I have a good bit of damage to my left atrium and I'm prone to kick back into a-fb and flutter.
Started taking Mg, CoQ10, L-carnitine and Ribose per Sinatra's recommendations .... and I feel great!