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Dr. Sinatra's Healthy Recipes

Dr. Sinatra’s Healthy Recipes

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Supplementation with what I've nicknamed, the “awesome foursome,” is the most targeted way of sustaining your heart’s energy needs. Supplements enhance health at the cellular level and provide nutrients necessary for metabolic processes. The “awesome foursome,” consisting of coenzyme Q10 (CoQ10), L-carnitine, D-ribose, and magnesium, individually and collectively help increase energy, or ATP, production in your body by supporting mitochondria within cells.

Everyone needs a sustained and healthy pool of ATP to fuel bodily functions. Cells require large amounts of ATP to contract and relax the heart, maintain cellular ion balance, and synthesize macromolecules like proteins and fats. Your body generates ATP de novo as well as recycles it through a process called oxidative phosphorylation. A much faster process than synthesizing ATP from scratch, recycling is the preferred method of energy production. Eighty to ninety percent of ATP is recycled in the mitochondria, then released into the fluid portion of cells to be used for energy.

Mitochondria require each of the “awesome foursome” to generate ATP. While CoQ10 and L-carnitine are fundamental to the ATP recycling process, D-ribose is necessary for de novo ATP synthesis. Metaphorically, D-ribose helps fill the body’s gas tank while L-carnitine and CoQ10 help the body convert fuel to energy. Literally, D-ribose is a structural component of the ATP molecule, and L-carnitine and CoQ10 help recycle ATP by transporting fatty acids across mitochondrial membranes and shuttling electrons back and forth between enzymes, respectively. Co-Q10 then acts as an antioxidant to protect mitochondrial membranes from free-radical damage. Like a spark plug central to both processes, magnesium “turns on” the enzymes that drive the entire metabolic reaction.

Supplementation Helps Prevent “Revolving-Door Medicine”

Depending on the individual, supplementation with any or all of the “awesome foursome” may be the key to maintaining energy and supporting overall health. At around age forty, endogenous production of CoQ10 and L-carnitine generally starts to decrease, explaining why people commonly associate lack of energy with “middle age.”

People suffering from coronary artery disease (CAD) often can't keep up with the heart's energy demands. With CAD, the heart continually overworks to pump blood through inflamed and congested blood vessels and ultimately expends energy must faster than the mitochondria can produce it.

If you take pharmaceutical drugs for CVD, you should also supplement with some or all of the "awesome foursome" to prevent nutrient deficiency. Beta blockers, for example, which prove effective in stabilizing people during emergency situations and improving symptoms, inhibit the production of enzymes necessary for CoQ10 synthesis. Since their long term use can impair your ability to make ATP, adjunctive supplementation with CoQ10 can counteract pharmaceutical side effects associated with energy depletion.

Most cardiologists want to avoid practicing “revolving-door medicine,” or repeatedly seeing the same patients come in with the same life-endangering problems. To make this happen, physicians and patients need to do something which moves beyond symptoms of the disease and gets to the “heart of the matter.” Complimenting pharmaceutical treatments with nutritional supports is one way that practitioners can treat symptoms and make a real difference in the underlying pathology of illness (emotional work and stress management are additional means).

Already native to your body, any of all of the “awesome foursome” can safely and effectively be ingested in tandem with cardiac drugs like beta-blockers, calcium channel blockers, nitrates, and ACE inhibitors. Not only will taking energy-enhancing supplements help alleviate negative side effects associated with these drugs, but it might eventually reduce, or even eliminate, your need for such medication.

Please note: although drug interactions are not likely, they are possible. Always consult with your physician before adding nutraceuticals to the program if you are currently taking pharmaceutical drugs for any cardiac condition.

More about the “awesome foursome”…

           Coenzyme Q10

            L-carnitine

            D-ribose

            Magnesium

In a nutshell

A healthy ATP energy pool can help keep you feeling youthful. While you can’t take ATP as a pill or vitamin, you can give your body the next best thing: substances with which it can make ATP. Supplementing with the “awesome foursome,” can help boost ATP production and support heart health. By directing nutrition to the cellular level, you can improve your quality of life, especially if you’re taking pharmaceutical medications and/or living with a cardiovascular condition.

People with heart disease often exhibit CoQ10, L-carnitine, D-ribose, and/or magnesium deficiencies. Failing hearts lack adequate energy to drive pump function. As the heart is one of the most responsive organs in the body for targeted nutritional supplementation, practicing metabolic cardiology is a must. By enhancing ATP synthesis and recycling, and promoting more efficient metabolism in mitochondria, the “awesome foursome” helps support heart health. Taking some or all of the “awesome foursome” adjunctive to pharmaceutical treatment can benefit those with a broad spectrum of cardiac conditions like angina, congestive heart failure, ventricular arrhythmia, hypertension, and high cholesterol. Patients should always consult with their physicians before adding nutritional supplements to a pharmacologic program.

Each of these nutrients plays a fundamental role in cellular metabolism, especially in supplying the heart with the energy it needs to preserve its contractile force. While each is independently effective in helping hearts work through the stress of disease, the “awesome foursome,” together, are synergistic.

For more information about the “awesome foursome” and ATP production, check out articles in the Metabolic Cardiology section, as well as my books:

© 2015 Heart MD Institute. All rights reserved.

 

 

 

Comments

  • # Blanche E. Baker

    Unlike +7

    You may be interested to know that my cardiologist was impressed with the improvements in all my labs that he wants to know what I'm taking, and who's advice I'm following.
    I've sent him copies of Health Radar articles, some quoting your comments and a list of all my "additives" from the Health Food Store.
    Inflammation has gone down from 4.5 to 1.3.

  • # Christi Cisek

    In reply to: Blanche E. Baker Unlike +1

    Curious what supplements you are taking, how much and how often you take them to reduce your inflammation. Just had my first echo at 50 as I have heart disease on both sides of my family. The stress test was perfect as was the EKG but the echo showed left ventricular inflammation. I am having heart pain daily. I just started Magnesium oil on the bottoms of my feet, am drinking more water and increased my Omega 3 and 6. I'm wondering if I should start the awesome foursome and how often to do it. Any help you could offer would be most appreciated! Thank you!

  • # Don Pacifico

    Unlike +1

    Does the "awesome foursome" help with fibrotic tissue associated with Restrictive Cardiomyopathy

  • # Richard Kurylski

    Unlike +12

    Dr Sinatra is always awesome. I wanted to know how CoQ10, L-carnitine and D-ribose are produced. Hope they are not synthetized. And what kind of magnesium is better absorbed because it is in a chemical compound.
    Does the "awesome foursome" help clean a calcified aortic valve that does not close properly? I heard that EDTA together with K2 (MK7) should be used. And probably L-arginine must be taken as well in order not to allow for the blood coagulation. But what doses and how should these be taken? Thank you.

  • # Magkayla Alexander

    Unlike +3

    Good morning DR. My son is 3-years old was born with TA stenosis, he will be do for the last procedure hopefully, and the dDoctor noticed that his tonsils are getting very big, now they want me to remove them from my son. What should I do?

  • # Richard Sherman

    Unlike +2

    Hi Dr Sinatra,

    Read the book on Earthing that reminded me of the book I read 15 years ago approx on the Cholesterol myth. I now have a 100% blocked LAD artery and my Cardiologist agrees that i shouldn't do anything but monitor it. I take supplements LysineC 1000 6x per day plus Vit C 4000 mg twice. Also Magnesium 500 mg and CoQ10 600 mg per day plus Nattokinase. My Cardiologist has me taking Livalo 1 mg , Amlodipine 2.5 and Metropolo 25mg. Now I'm not feeling as well as i did two weeks ago... Have had EKGs of normal plus CTA test showing calcification. Wanted to know if you could recommend a Cardiologist for another opinion who follows Alternatives as yourself since I see you are retired.. Thanks for all the information ..Appreciated Rich

  • # Richard Sherman

    Unlike +1

    I think I don't feel well now due to the meds.. I workout, eat well and no carbs and also do meditational practice to assist my heart. added this to clarify why i don't feel well. Had a nuclear stress and another regular to push me to see how well and i did excellent with the blockage.. Have created two bypasses by myself . thanks again

  • # Joe

    Unlike +17

    What brands are recommended for the awesome foursome and amounts per day for men and women?

  • # Judy

    Unlike +1

    If you are over 30 years old, you should be taking Ubiquinol (a form of CoQ10 that makes it easily bioavailable to use by the body).

  • # David Simcho

    Unlike +1

    What is a good ATP increase over a 30 day period.

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